Category Research Programs and Funding Opportunities   Show all

  • “Insights” on Simulation Modeling and Systems Science, New Research Funding Opportunity

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    By Xinzhi Zhang, M.D., Ph.D.
    Program Director, Division of Scientific Programs
    National Institute on Minority Health and Health Disparities

    There are many contributing factors to health, such as race, ethnicity, sex, sexual identity, age, disability, socioeconomic status, and geographic location. To help close health gaps, the National Institute on Minority Health and Health Disparities (NIMHD) spearheads scientific research at the National Institutes of Health (NIH) to improve minority health and reduce health disparities.

    NIMHD is leading a new Funding Opportunity Announcement (FOA): Simulation Modeling and Systems Science (SMSS) to Address Health Disparities. To learn more about SMSS and this new funding opportunity, NIMHD Program Officer Dr. Xinzhi Zhang addresses a few questions for the Insights blog.

    Dr. Xinzhi Zhang

    What is simulation modeling and systems science?

    Systems science considers different components within complex systems across multiple levels to help understand their interactions and influences. The dynamic relationship that unfolds when considering the many factors that contribute to health inequities, such as segregation, food insecurity, and neighborhood safety, to name a few, cannot be fully captured with currently available data and analytic methods. Simulation modeling and systems science (SMSS) is a tool that tests plausible scenarios and helps us understand the magnitude of intended and unintended consequences of specific interventions. It also provides options to adjust and/or refine simulated intervention designs prior to actual implementation testing in the real world.

    In what ways can SMSS help us better understand minority health and health disparities?

    Although we know simulation models cannot replace real-world settings or scenarios, many simulation models are becoming indispensable for decision making, such as in national or local pandemic planning. SMSS can also have a profound impact on health policies relevant to minority health and health disparities.

    In a variety of fields, SMSS approaches have been used to guide interventions in clinical preventive care and disaster planning as well as analyze national health reform strategies. SMSS has also been used to model potential public health outcomes in cases where it is not feasible to test various intervention strategies on real populations, particularly where interventions may involve factors far upstream from health outcomes, such as societal causes embedded in political, legal, economic, and cultural factors.

    How will NIMHD support SMSS research?

    NIMHD is interested in several research priorities that could have significant impact on our knowledge of minority health and health disparities research. Specific examples of research topics can be found in the Simulation Modeling and Systems Science to Address Health Disparities FOA.

    Will any other NIH Institutes or Centers participate in this funding opportunity?

    Yes. In addition to NIMHD, nine other NIH Institutes, Centers, and Offices are participating in the Simulation Modeling and Systems Science to Address Health Disparities FOA:

    • National Cancer Institute (NCI)
    • National Heart, Lung, and Blood Institute (NHLBI)
    • National Institute on Aging (NIA)
    • National Institute on Deafness and Other Communication Disorders (NIDCD)
    • National Institute on Drug Abuse (NIDA)
    • National Institute of Mental Health (NIMH)
    • National Library of Medicine (NLM)
    • Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), Office of Disease Prevention (ODP)
    • Office of Behavioral and Social Sciences Research (OBSSR)

    The due date for the first round of applications is January 7, 2018. Applicants are encouraged to read the entire Simulation Modeling and Systems Science to Address Health Disparities funding opportunity announcement at to get additional information about the application process.

  • NIMHD Loan Repayment Programs

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    By Dorothy M. Castille, Ph.D.

    Health Scientist Administrator, Division of Scientific Programs
    National Institute on Minority Health and Health Disparities

    The National Institute on Minority Health and Health Disparities (NIMHD) invites qualified health professionals who contractually agree to engage in NIH mission–relevant research to apply for the 2018 extramural NIMHD Loan Repayment Programs (LRP) for an average of at least 20 hours per week for at least two years. Descriptions of the NIMHD LRP follow:

    The objectives of these congressionally established and designed programs are to recruit and retain qualified health professionals into research careers that focus on minority health disparities or other health disparities or to recruit and retain qualified health professionals from disadvantaged backgrounds into clinical research careers. The Extramural LRPs repay up to $35,000 of a researcher’s qualified educational debt annually, in return for a commitment to engage in NIMHD mission–relevant research at a domestic, nonprofit, or government entity. Educational eligibility criteria require that applicants possess a doctoral-level degree from an accredited institution.

    All applications must be completely submitted, including all recommenders’ letters, via the applicant’s eRA Commons account by 8:00 PM EST on November 15, 2017.

    In conjunction with this program, NIMHD hosted a Technical Assistance Webinar on Thursday, October 5, 2017. The purpose of the webinar was to discuss the program’s goal, the application process (including recent revisions to it), components of an application that are competitive and responsive to the funding opportunity announcements, criteria for review of applications, and the financial vetting process.

    To learn more about NIMHD’s Loan Repayment Program, visit

    To view information from NIMHD’s LRP Technical Assistance Webinar, visit

    For more information about the program or to get feedback on a previous application, please contact:

    Dorothy M. Castille, Ph.D.

    Adelaida Rosario, Ph.D.
    Former NIMHD Program Officer

    Vincent Thomas, M.S.W., M.P.A.
    Former NIMHD Staffer

  • For the First Time, Healthy People Initiative Focuses on Social Determinants of Health

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    By Nancy Breen, Ph.D.
    Economist, Office of Strategic Planning, Analysis and Reporting, NIMHD and NIMHD Representative to the Healthy People Social Determinants of Health Workgroup

    Healthy People Background

    The Healthy People initiative is a federal program that provides “science-based, 10-year national objectives for improving the health of all Americans.” For the past 40 years, Healthy People has monitored the health of Americans and set benchmarks for how we can all be healthier. You can read more about Healthy People online at

    Healthy People provides a national 10-year framework for health promotion and disease prevention, with measurable objectives and goals, and it invites states and localities to use the national framework and objectives for their own plans. While the focus has always been health promotion and disease prevention, the Healthy People 2020 agenda is the first to use social determinants of health (SDOH) to frame the conceptual understanding of health. For 2000, an overarching goal to “reduce health disparities” was introduced, partly in response to the 1985 Report of the Secretary’s Task Force Report on Black and Minority Health (often referred to as the “Heckler Report”).1 For 2010, that goal was strengthened to “eliminate health disparities.” For Healthy People 2020, one of the overarching goals is to “achieve health equity, eliminate disparities, and improve the health of all groups.”2 The graphic from Healthy People 2020 shows that the overarching goals emphasize the determinants of health.

    The mission of Healthy People 2020 includes identifying health improvement priorities; increasing public understanding of the determinants of health, disease, and disability; and engaging multiple sectors to identify opportunities for progress. Including health disparities in this framework improves the chances that federal interventions will be able to reduce health disparities and increase health equity for all Americans. The choice to highlight social determinants as a leading health indicator (LHI) is important, because LHIs are used to motivate action on high-priority health issues and challenges at the national, state, and community levels.3

    One of the Healthy People initiative’s key roles is to identify research, evaluation, and data needs. The National Center for Health Statistics conducts two assessments for each 10-year initiative. These midcourse and final reviews provide an opportunity to see the initiative’s impact along the way. The 5-year review for Healthy People 2020 was released in January 2017 and can be found on the CDC website, at

    Healthy People 2020 Framework. Graphic from

    Chapter 39 of the Midcourse Review focuses on SDOH, and some of the most important findings are described below. Healthy People 2020 defines SDOH as “conditions and the environment in which people are born, live, learn, work, play, worship, and age that affect a wide range of health, functioning, and quality-of-life outcomes and risks.”4 The 33 SDOH objectives are organized into five domains:

    1. Economic stability (9 objectives)
    2. Education (5 objectives)
    3. Health and healthcare (6 objectives)
    4. Neighborhood and built environment (10 objectives)
    5. Social and community context (3 objectives)

    Highlights from the Midcourse Review

    Economic Stability

    How much money people spend on housing can have a meaningful impact on their well-being. Economic experts recommend that families spend no more than one third of their income on housing, so that adequate funds are available for other expenditures. Studies show that spending more than half of a family’s income on housing puts householders at high risk of losing their home. The Midcourse Review shows that more people are being affected on both measures, suggesting that, overall, Americans are not doing as well in terms of economic stability as they were 5 years before.

    • From 2007 to 2011, the proportion of households that spent more than 30 percent of their income on housing rose from 35 percent to 38 percent; in 2011, Hispanics/Latinos were the racial/ethnic group most at risk. Householders with less than a high school education, with low family income, with a disability, or who lived in metropolitan areas were also at higher risk.
    • From 2007 to 2011, the proportion of households that spent more than half of their income on housing increased from 16 percent to 18 percent. Householders who were African American had less than a high school education, were poor, or lived in nonmetropolitan areas were at higher risk.


    Today, having a college education is important for getting a job and staying employed. The Midcourse Review showed that, unfortunately, the percentage of young people going to college after completing high school is lower than it was a few years ago.

    • Individuals ages 16–24 who had completed high school and enrolled in college the following October decreased from 68 percent to 66 percent between 2010 and 2013. High school completers from low-income families were less likely than completers from high-income families to enroll in college right after high school graduation.

    Health and Healthcare

    Having health insurance is an important part of making sure that people can afford access to an ongoing source of healthcare when they get sick. The Midcourse Review showed that more people under the age of 65 have insurance now than they did in 2007 and that people of all ages are more likely to have a source of ongoing healthcare. In addition, more people than before say that they can understand their doctor or nurse’s instructions.

    • The proportion of people under age 65 with medical insurance increased from 83 percent in 2008 to 87 percent in 2014, and the proportion of people of all ages with a source of ongoing care increased from 86 percent in 2008 to 88 percent in 2014.
    • The proportion of people age 18 and over who reported that their healthcare providers’ instructions were easy to understand increased from 64 percent in 2011 to 66 percent in 2012.

    Neighborhood Context and the Built Environment

    Under the well-known “broken windows” theory, an orderly environment signals that an area is monitored and that criminal behavior is not tolerated: Neighborhoods with a strong sense of cohesion assert social responsibility and control by fixing broken windows and other small but visible problems. Air quality and lead levels are important indicators of a clean and safe environment, and crime rates are an indicator of social cohesion.

    • Between 2008 and 2012, there was a decrease in the rate of arrests of minors and young adults ages 10–24 for serious violent crimes (from 444 to 324 per 100,000 population) and serious property crimes (from 1,527 to 1,223 per 100,000 population).
    • Days when the Air Quality Index (AQI) exceeded 100 (weighted by population and AQI) decreased from 2.2 billion to 982 million between 2006–2008 and 2012–2014. Also, lead levels in blood samples among children ages 1–5 years in the 97.5 percentile decreased from 5.8 mcg/dL to 4.3 mcg/dL between 2005–2008 and 2009–2012.

    Social and Community Context

    Social support is especially critical for children and adolescents, who are in their formative years. New items that may be measured in the final review of Healthy People 2020 include civic participation, incarceration, and discrimination.

    • The proportion of adolescents ages 12–17 who reported having an adult in their lives with whom they could discuss serious problems rose slightly, from 76 percent in 2008 to 78 percent in 2013; however, it is striking that almost a quarter of adolescents did not report having such an adult in their lives.

    Overall, the Healthy People 2020 Midcourse Review underscores a basic fact: Improving the social determinants of health and mitigating their adverse impacts on population health is complicated. Even so, trends for 15 of the 25 objectives that have targets are moving toward or have met national targets. The Midcourse Review provides an opportunity to assess progress and identify remaining opportunities for interventions so that more can be accomplished by 2020. Addressing SDOH in localities, states, and the nation is an important step toward reducing health disparities. We have made some progress, especially in healthcare and family communication, but there is still work to be done.

    Learn more about NIMHD’s work to eliminate disparities and improve the health of all groups.


    1. National Center for Health Statistics. Chapter 4: Leading Health Indicators. Healthy People 2020 Midcourse Review. Hyattsville, MD. 2016.

    2. National Center for Health Statistics. Chapter 39: Social Determinants of Health (SDOH). Healthy People 2020 Midcourse Review. Hyattsville, MD. 2016.

    3. U.S. Department of Health and Human Services. Report of the Secretary’s Task Force on Black and Minority Health. Volume I: Executive Summary. Washington, DC. 1985.

    4. National Center for Health Statistics. Chapter 1: Introduction. Healthy People 2020 Midcourse Review. Hyattsville, MD. 2016.